Publication:
Selected Publications: Chlamydomonas Source Book Chapter: Deflagellation by Dr. Lynne Quarmby (2008) [In press, View PDF] Katanin knockdown supports a role for microtubule severing in release of basal bodies prior to mitosis in Chlamydomonas The NIMA-family kinase, Nek1 affects the stability of centrosomes and ciliogenesis NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. Defects in ciliary localization of Nek8 is associated with cystogenesis. Phylogenetic analysis of the Neks reveals early diversification of ciliary-cell cycle kinases. Caught Nek-ing: cilia and centrioles. NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. A NIMA-related kinase, Cnk2p, regulates both flagellar length and cell size in Chlamydomonas. Cilia and the cell cycle? A NIMA-related kinase, Fa2p, localizes to a novel site in the proximal cilia of Chlamydomonas and mouse kidney cells.
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